Gγ13 Interacts with PDZ Domain-containing Proteins
نویسندگان
چکیده
منابع مشابه
The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis
Spine function requires precise control of the actin cytoskeleton. Kalirin-7, a GDP/GTP exchange factor for Rac1, interacts with PDZ proteins such as PSD-95, colocalizing with PSD-95 at synapses of cultured hippocampal neurons. PSD-95 and Kalirin-7 interact in vivo and in heterologous expression systems. In primary cortical neurons, transfected Kalirin-7 is targeted to spines and increases the ...
متن کاملViral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?
Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interactio...
متن کاملCD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.
CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. Recent studies using mice deficient in CD93 have demonstrated that this molecule modulates phagocytosis of apoptotic cells in vivo. To investigate signal transduction mechanisms mediated...
متن کاملGIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP.
We have identified a mammalian protein called GIPC (for GAIP interacting protein, C terminus), which has a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. The PDZ domain of GIPC specifically interacts with RGS-GAIP, a GTPase-activating protein (GAP) for Galphai subunits recently localized on clathrin-coated vesicles. Analysis of deletion mutants indicated that the PDZ dom...
متن کاملRole of PDZ domain-containing proteins and ERM proteins in regulation of renal function and dysfunction.
Hormonal, dietary, and metabolic factors play an important role in regulation of renal proximal tubular apical membrane sodium-hydrogen (Na/H) exchange and sodium-phosphate (Na/Pi) cotransport and basolateral membrane sodium-potassium-ATPase (Na-K-ATPase) activity by diverse cellular mechanisms including transcriptional, translational, and posttranslational mechanisms. Recent work in this area ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m600113200